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No endogenous compounds were found around the retention time. The inter- and intra-day precision and accuracy were 4. The mean total area under the curve AUC 0-infinity were Azelastine hydrochloride is a novel chemical entity that has been developed as an long-acting anti-allergic and asthma-prophylactic agents that possesses properties with histamine-H1 receptor-antagonistic activity and antagonism of the various chemical mediators such as adenosine, leukotriene, endothelin-1, platelet activation factor PAF and superoxide-free radicals 1, 2. Azelastine prevents and attenuates chemical mediators- and exercise-induced bronchoconstriction 3, 4, therefore it has been used as asthma prophylactic and anti-allergic agents orally or nasally with long duration of action in adults and children 5, 6.

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